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Manufacturers supply cost-effective and customizable (1-hydroxycyclopentyl)phenylacetic acid 25209-52-3
- Molecular Formula: C13H16 O3
- Molecular Weight: 220.268
- Vapor Pressure: 1.36E-06mmHg at 25°C
- Boiling Point: 384.3°Cat760mmHg
- Flash Point: 200.4°C
- PSA： 57.53000
- Density: 1.263g/cm3
- LogP: 2.15990
(1-hydroxycyclopentyl)phenylacetic acid(Cas 25209-52-3) Usage
|
Definition |
ChEBI: (1-hydroxycyclopentyl)acetic acid in which one of the hydrogens alpha to the carboxylic acid group is substituted by a phenyl group. |
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Synthesis Reference(s) |
Journal of the American Chemical Society, 73, p. 4221, 1951 DOI: 10.1021/ja01153a053 |
InChI:InChI=1/C13H16O3/c14-12(15)11(10-6-2-1-3-7-10)13(16)8-4-5-9-13/h1-3,6-7,11,16H,4-5,8-9H2,(H,14,15)
25209-52-3 Relevant articles
Stereospecific Electrophilic Fluorocyclization of α,β-Unsaturated Amides with Selectfluor
Fei, Haiyang,Fu, Yao,Jalani, Hitesh B.,Li, Guigen,Lu, Hongjian,Wu, Hongmiao,Xu, Zheyuan,Zhu, Lin
supporting information, (2020/03/30)
An efficient fluorocyclization of α,β-un...
Preparation method of cyclopentolate hydrochloride intermediate
-
Paragraph 0009; 0024-0031, (2019/12/02)
The invention belongs to the technical f...
Preparation method of cyclopentolate hydrochloride
-
Paragraph 0014; 0048-0050, (2017/05/04)
The invention relates to a preparation m...
OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF
-
Paragraph 0445-0446, (2013/09/26)
Compounds of Formula (I) and Formula (II...
25209-52-3 Process route
-
-
103-82-2
phenylacetic acid
-
-
120-92-3
cyclopentanone
-
-
25209-52-3
α-(1-Hydroxycyclopentyl)phenylessigsaeure
| Conditions | Yield |
|---|---|
|
phenylacetic acid;
With
3-methylphenylmagnesium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
cyclopentanone;
In
tetrahydrofuran;
at 35 ℃;
for 1h;
Reagent/catalyst;
Temperature;
|
85.6%
|
|
phenylacetic acid;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
Inert atmosphere;
cyclopentanone;
In
tetrahydrofuran;
at -60 - 20 ℃;
for 10h;
Solvent;
Reagent/catalyst;
Temperature;
Inert atmosphere;
|
71%
|
|
phenylacetic acid;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at 0 - 20 ℃;
cyclopentanone;
In
tetrahydrofuran;
at -78 - 20 ℃;
|
3.5 g
|
|
phenylacetic acid;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at 40 ℃;
for 1h;
cyclopentanone;
In
tetrahydrofuran;
at 25 - 40 ℃;
for 1h;
|
-
-
103-82-2
phenylacetic acid
-
-
920-39-8
isopropylmagnesium bromide
-
-
120-92-3
cyclopentanone
-
-
25209-52-3
α-(1-Hydroxycyclopentyl)phenylessigsaeure
| Conditions | Yield |
|---|---|
|
|
25209-52-3 Upstream products
-
103-82-2
phenylacetic acid
-
920-39-8
isopropylmagnesium bromide
-
120-92-3
cyclopentanone
-
114-70-5
sodium phenylacetate
25209-52-3 Downstream products
-
752943-22-9
(1-hydroxy-cyclopentyl)-phenyl-acetic acid-(2-piperidino-ethyl ester)
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126497-27-6
2-cyclopentylidene-1-phenylacetic acid
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4410-77-9
benzylidenecyclopentane
-
55930-33-1
N-Hydroxy-2-(1-hydroxy-cyclopentyl)-2-phenyl-acetamide
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